Click here for the the meeting program in PDF.
| Monday, July 20 | ||
|---|---|---|
| 12:00 – 2:00 | Arrival and Registration | Conference Lobby |
| 2:00 | Welcome: Dr. Stephen Plymate & Dr. Peggy Porter | Cascade Locks Ballroom |
| SESSION I New Insights on Genetic Susceptibility to Breast and Prostate Cancers Chairs: Dr. Carol Lange & Dr. Donald Tindall Discussants: Dr. Colleen Nelson & Dr. Andrei Goga |
Cascade Locks Ballroom | |
| 2:15 | Mathieu Lupien, PhD Identifying the target genes of breast cancer genetic predispositions |
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| 2:25 | Massimo Loda, MD Role of stroma in prostate development, maintenance and metastasis |
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| 2:35 | Stephen Plymate, MD Allosteric Alterations in the Androgen Receptor Determine Activity in Prostate Cancer |
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| 2:45 | Jyotsna Batra, PhD A large scale association analysis of miRSNPs with prostate cancer |
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| 2:55 | Melissa Davis, BSc, PhD Gene regulatory network analysis |
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| 3:05 – 4:00 | Open Discussion | |
| 4:00 | Break | |
| 4:30 – 5:30 | Ron Ross Oration & Award Presented by: Professor Juergen Reichardt & Professor Wayne Tilley Recipient: Leslie Bernstein, PhD City of Hope National Medical Center |
Cascade Locks Ballroom |
| 5:30 – 7:00 | Free Time | |
| 7:00 – on | Opening Reception / Dinner | Cascade Lawn |
| 8:00 –10:00 | Prostate SPORE Meeting (PNW Prostate SPORE EAB/IAB only) | Baker Room |
| Tuesday, July 21 | ||
| 6:30 | Breakfast | Conference Lobby |
| SESSION II Advances in Imaging Local and Distant Disease Chairs: Dr. Massimo Loda & Dr. Kenneth Pienta Discussants: Dr. Martin Gleave & Dr. Judith Clements |
Cascade Locks Ballroom | |
| 8:30 | Evan Yu, MD PET imaging in prostate cancer: Research tool or standard clinical practice? |
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| 8:40 | Daniel Lin, MD Imaging in Localized Prostate Cancer |
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| 8:50 | Constance Lehman, MD, PhD Breast MRI in Local Disease |
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| 9:00 | Howard Scher, MD PSMA Imaging in Prostate Cancer For Specific Contexts of Use |
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| 9:10 – 10:00 | Open Discussion | |
| 10:00 | Break | |
| Sponsored by: Janssen Pharmaceutical Companies of Johnson & Johnson SESSION III ER, AR and other Nuclear Hormone Receptors in the Biology and Treatment of Breast and Prostate Cancer Chairs: Dr. Amina Zoubeidi & Dr. Luc Furic Discussants: Dr. Xuesen Dong & Dr. Edward Gelmann |
Cascade Locks Ballroom | |
| 10:30 | Yan Dong, PhD Dimerization is Required for Androgen Receptor Splice Variants to Regulate Gene Expression and Promote Castration-Resistant Cell Growth |
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| 10:40 | Theresa Hickey, PhD Crossing Paths: sex steroid receptor interaction in breast cancer |
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| 10:50 | Nancy Weigel, PhD Androgen Receptor Isoforms Differentially Regulate Cell Metabolism in Prostate Cancer Cells |
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| 11:00 | Geoffrey Greene, PhD Progesterone Receptor is a Non-Competitive Agonist of Estrogen Receptor and is Essential for Breast Cancer Prognosis |
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| 11:10 | Margaret Yu, MD AR directed therapies in Prostate cancer Today and Tomorrow |
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| 11:20 | Suzanne Fuqua, PhD ESR1 Mutations Escape Hormone Therapy through Activation of IGF1R in Breast Cancer |
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| 11:30 | Karen Knudsen, PhD Targeting hormone-DNA repair crosstalk in prostate cancer: mechanisms and implications for therapeutic intervention |
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| 11:40 | Wayne Tilley, PhD Progesterone receptor directs a distinct estrogen receptor-α chromatin binding profile in breast cancer to elicit good clinical outcome |
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| 11:50 – 1:00 | Open Discussion | |
| 1:00 | Lunch | Cascade Dining Room |
| Sponsored by Fred Hutch/University of Washington: Cancer Consortium SESSION IV Novel Strategies for Developing and Deploying ‘Precision Oncology’ Therapeutics Chairs: Dr. Paul Rennie & Dr. Alexander Wyatt Discussants: Dr. Donald Tindall & Dr. Brett Hollier |
Cascade Locks Ballroom | |
| 2:00 | Natasha Kyprianou, PhD Novel Action of Cabazitaxel in Prostate Cancer |
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| 2:10 | Jun Luo, PhD Non-invasive detection of the aberrant AR in prostate cancer |
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| 2:20 | Himisha Beltran, MD Lessons from Exceptional Responders |
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| 2:30 | Christopher Sweeney, MBBS Precision medicine in a heterogenous world |
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| 2:40 | Bruce Montgomery, MD Biallelic inactivation of BRCA2 in metastatic castration resistant prostate cancer is associated with platinum sensitivity |
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| 2:50 | Greg Monteith, BPharm, PhD Regulation of hypoxia-associated epithelial to mesenchymal transition by plasmalemmal ion channels in breast cancer cells |
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| 3:00 | Roxana Schillaci, PhD Targeting Tumor Necrosis Factor alpha as a Novel approach to Overcome Breast Cancer Resistance |
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| 3:10 – 4:00 | Open Discussion | |
| 4:00 | Free Time | |
| 5:30 | Poster Session with Refreshments (room will remain open all week) | Stevenson C/D |
| 7:00 on | Dinner | Ampitheatre |
| Wednesday, July 22 | ||
| 6:30 | Breakfast | Conference Lobby |
| SESSION V Risk Assessment: Tumor, Host, Environment Chairs: Dr. Andrei Goga & Dr. Lenora Loo Discussants: Dr. Christopher Ong & Dr. Janet Stanford |
Cascade Locks Ballroom | |
| 8:30 | Christopher Li, MD, PhD Challenges and Opportunities in Risk Assessment across the Breast Cancer Spectrum” |
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| 8:40 | Gail Prins, PhD Distinct Actions of ERα and ERβ in Human Prostate Stem Cell Self-Renewal |
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| 8:50 | Jonathan Wright, MD The Prostate Cancer Active Lifestyle Study: An intervention in overweight men on active surveillance |
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| 9:00 | Alexander Swarbrick, PhD Paracrine Hedgehog signaling as a therapeutic target in triple negative breast cancer |
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| 9:10 | Peggy Porter, MD Ancestry and Risk of Breast Cancer in Hispanic/Latina Women |
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| 9:20 | Hironobu Sasano, MD, PhD Angiogenesis and tumor infiltrating lymphocytes in breast cancer : how we could assess? |
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| 9:30 – 10:30 | Open Discussion | |
| 10:30 | Break | Conference Lobby |
| Sponsored by Bayer SESSION VI Personalizing Prevention Strategies Chairs: Dr. Pete Nelson & Dr. Peggy Porter Discussants: Dr. Daniel Lin & Dr. Christopher Li |
Cascade Locks Ballroom | |
| 11:00 | Lorelei Mucci, ScD, MPH Is TMPRSS2:ERG a unique etiologic subtype of prostate cancer? |
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| 11:10 | Edward Gelmann, MD Molecular Inevitability of Prostate Cancer Initiation |
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| 11:20 | Elahe Mostaghel , MD, PhD SLCO Genes as Host and Tumor Determinants of Abiraterone Exposure and Treatment Efficacy |
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| 11:30 | Colleen Nelson, PhD Is it possible to prevent prostate cancer? |
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| 11:40 | Janet Stanford, PhD Etiologic heterogeneity in prostate cancer: risk factor profiles by TMPRSS2:ERG fusion status |
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| 11:50 | Erik Thompson, PhD High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium |
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| 12:00 | Open Discussion | |
| 1:00 | Grab and Go Boxed Lunch | Conference Lobby |
| Free afternoon and evening, Dinner (own arrangements) | ||
| Thursday, July 23 | ||
| 6:30 | Breakfast | Conference Lobby |
| Sponsored by NanoString Technologies SESSION VII Cancer Genomics and Epigenomics: TCGA and Beyond… Chairs: Dr. David Quinn & Dr. Juergen Reichardt Discussants: Dr. Mitchell Lawrence & Dr. Paul Rennie |
Cascade Locks Ballroom | |
| 8:00 | Elaine Ostrander, PhD Whole Exome Sequencing in Prostate Cancer Families Identifies Eight Previously Unknown Susceptibility Genes“ |
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| 8:10 | Michael Press, MD, PhD HER2 co-amplified genes: Potential role in treatment responsivenes |
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| 8:20 | Carol Lange, PhD Where Genetics meets Epigenetics: Context-Dependent SR Actions in Breast/Ovarian Cancers |
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| 8:30 | Luke Selth, PhD Androgen receptor “interactomics” identifies GRHL2 as a novel co-regulator |
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| 8:40 | Paul Spellman PhD Studying Early Tumor Evolution |
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| 8:50 | Joshi Alumkal , MD Integrative Genomic Analysis to Identify Emergent Enzalutamide Resistance Mechanisms in Castration-Resistant Prostate Cancer |
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| 9:00 – 10:00 | Open Discussion | |
| 10:00 | Break | Conference Lobby |
| SESSION VIII Tumor Microenvironments: Influence on Tumor Development, Tumor Progression, and Therapy Resistance Chairs: Dr. Ralph Buttyan & Dr. Natasha Kyprianou Discussants: Dr. Christina Curtis & Dr. Michael Press |
Cascade Locks Ballroom | |
| 10:30 | Shoukat Dedhar, PhD Breast cancer metastasis and hypoxia |
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| 10:40 | Jeff Holst, PhD Regulation of amino acid uptake coordinates adaptive cancer cell metabolism |
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| 10:50 | Peter Nelson, MD Tumor Microenvironment-Mediated Resistance to Cancer Therapeutics: Targeting Master Regulators |
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| 11:00 | Marina Simian PhD The extracellular matrix determines ER-alpha’s longevity by an endosomal recycling pathway: implications for endocrine resistance in breast cancer |
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| 11:10 | Mitchell Lawrence, PhD Surveying the epigenome landscape of the prostate cancer microenvironment |
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| 11:20 | Andrei, Goga, MD, PhD Novel Therapy of MYC Elevated Triple-Negative Breast Cancers by Targeting Fatty Acid Oxidation |
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| 11:30 – 12:20 | Open Discussion | |
| 12:20 | Lunch | Yurt Area |
| SESSION IX Developing and Utilizing Clinically-Relevant Models of Breast and Prostate Cancer Chairs: Dr. Judith Clements & Dr. Elizabeth Williams Discussants: Dr. Amina Zoubeidi & Dr. Cyrus Ghajar |
Cascade Locks Ballroom | |
| 1:20 | Kenneth Pienta, MD Modeling dormancy in prostate cancer |
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| 1:30 | Ralph Buttyan, PhD Development and Utilization of a Novel Paradigm for Generating a Neural Class of Prostate Cancer Stem Cells That Yields a Gene Signature of Adverse Outcomes in Patients with the Disease |
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| 1:40 | Hong Wu, MD, PhD How Genetically Engineered Mouse Models Provide Insights into Human Prostate Cancer and Therapeutics |
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| 1:50 – 2:30 | Open Discussion | |
| In Memory of Rob Sutherland SESSION X Metastasis: Understanding Mechanisms To Enhance Effective Targeting Chairs: Dr. Erik Thompson & Dr. Brett Hollier Discussants: Dr. Stephen Plymate & Dr. Wayne Tilley |
Cascade Locks Ballroom | |
| 2:30 | Steve Balk, MD, PhD SOX9 regulates WNT/Beta-catenin signalling in prostate cancer |
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| 2:40 | Paul Rennie PhD, FCAHS Development of small molecule inhibitors of ERG to treat metastatic prostate cancer |
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| 2:50 | Patricia Elizalde, PhD Nuclear ErbB-2 Induces Breast Cancer Metastasis |
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| 3:00 | Cyrus Ghajar, PhD Targeting the ‘dormant niche’ to prevent metastasis |
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| 3:10 – 4:00 | Open Discussion | |
| 4:00 – 4:30 | Conclusions – Stephen Plymate & Peggy Porter | Cascade Locks Ballroom |
| 5:00 | Happy Hour | Columbia Gorge Interpretive Center |
| 5:45 | The Great Debate: Testing Precision Medicine: N of 1 vs. N of Many | Columbia Gorge Interpretive Center |
| 7:00 on | Farewell Dinner | Columbia Gorge Interpretive Center |
| Friday, July 24 | ||
| 6:30 – 11 | Breakfast & 11:00AM Check Out | Cascade Dining Room |